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Istradefylline 40 mg/working day amplified peak concentrations and AUC of CYP3A4 substrates in medical trials. This influence was not observed with istradefylline 20 mg/day. Take into account dose reduction of sensitive CYP3A4 substrates.fosphenytoin will lower the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabol